Short wave instability of co-extruded elastic liquids with matched viscosities.

The stability of channel flow of coextruded elastic liquids having matched viscosities but a jump in elastic properties is studied. Inertia and surface tension are neglected. A short wave disturbance is found, confined near the interface, whose growth rate is independent of wavelength. For dilute Oldroyd-B fluids this disturbance is unstable for any non-zero jump in normal stresses, and has a maximum growth rate for intermediate levels of elasticity in the two fluids. When one or other fluid is highly elastic the growth rate falls. In the concentrated limit (a UCM fluid), the disturbance is unstable only for a finite range of normal stress jumps, and is restabilized if one fluid is much more elastic than the other. Because the short wave disturbance is localised, the results apply for any steadily sheared interface across which the normal stress jumps. The results are confirmed for moderate parameter values by means of a full numerical solution for a three-layer planar flow

Assessing sedimentation equilibrium profiles in analytical ultracentrifugation experiments on macromolecules: from simple average molecular weight analysis to molecular weight distribution and interaction analysis

Molecular weights (molar masses), molecular weight distributions, dissociation constants and other interaction parameters are fundamental characteristics of proteins, nucleic acids, polysaccharides and glycoconjugates in solution. Sedimentation equilibrium in the analytical ultracentrifugation provides a powerful method with no supplementary immobilization, columns or membranes required. It is particularly powerful when used in conjunction with its sister technique, namely sedimentation velocity analysis. We describe key approaches now available and their application to the characterisation of antibodies polysaccharides and glycoconjugates. We indicate how major complications such as thermodynamic non-ideality can now be routinely dealt with, thanks to a great extent to the extensive contribution of Professor DonWinzor over several decades of research

Numerical study of chemical reaction effects in magnetohydrodynamic Oldroyd B oblique stagnation flow with a non-Fourier heat flux model

Reactive magnetohydrodynamic (MHD) flows arise in many areas of nuclear reactor transport. Working fluids in such systems may be either Newtonian or non-Newtonian. Motivated by these applications, in the current study, a mathematical model is developed for electrically-conducting viscoelastic oblique flow impinging on stretching wall under transverse magnetic field. A non-Fourier Cattaneo-Christov model is employed to simulate thermal relaxation effects which cannot be simulated with the classical Fourier heat conduction approach. The Oldroyd-B non-Newtonian model is employed which allows relaxation and retardation effects to be included. A convective boundary condition is imposed at the wall invoking Biot number effects. The fluid is assumed to be chemically reactive and both homogeneous-heterogeneous reactions are studied. The conservation equations for mass, momentum, energy and species (concentration) are altered with applicable similarity variables and the emerging strongly coupled, nonlinear non-dimensional boundary value problem is solved with robust well-tested Runge-Kutta-Fehlberg numerical quadrature and a shooting technique with tolerance level of 10−4. Validation with the Adomian decomposition method (ADM) is included. The influence of selected thermal (Biot number, Prandtl number), viscoelastic hydrodynamic (Deborah relaxation number), Schmidt number, magnetic parameter and chemical reaction parameters, on velocity, temperature and concentration distributions are plotted for fixed values of geometric (stretching rate, obliqueness) and thermal relaxation parameter. Wall heat transfer rate (local heat flux) and wall species transfer rate (local mass flux) are also computed and it is observed that local mass flux increases with strength of heterogeneous reactions whereas it decreases with strength of homogeneous reactions. The results provide interesting insights into certain nuclear reactor transport phenomena and furthermore a benchmark for more general CFD simulations

Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO

The last three decades has seen some important advances in our ability to represent the conformation of proteins in solution on the basis of hydrodynamic measurements. Advances in theoretical modeling capabilities have been matched by commensurate advances in the precision of hydrodynamic measurements. We consider the advances in whole-body (simple ellipsoid-based) modeling—still useful for providing an overall idea of molecular shape, particularly for those systems where only a limited amount of data is available—and outline the ELLIPS suite of algorithms which facilitates the use of this approach. We then focus on bead modeling strategies, particularly the surface or shell–bead approaches and the HYDRO suite of algorithms. We demonstrate how these are providing great insights into complex issues such as the conformation of immunoglobulins and other multi-domain complexes

A rising bubble in a polymer solution

We propose a boundary integral method to study the shape of a bubble rising under gravity in a dilute polymer solution. Constitutive properties are modelled using a FENE model [M.D. Chilcott, J.M. Rallison, J. Non-Newtonian Fluid Mech. 29 (1988) 38 1] with a pure surface tension interface. We employ a birefringent strand representation [O.G. Harlen, J.M. Rallison, M.D. Chilcott, High-Deborah-number flows of dilute polymer, J. Non-Newtonian Fluid Mech.34 (1990) 319-349] of the wake to simulate the shape and the time-dependent motion of the bubble. Steady and non-steady solutions reproduce qualitatively the bubble deformation seen in experiment with a small region of very high curvature near the rear stagnation point of the bubble. We find a limit point for steady axisymmetric solutions if the polymer concentration is increased or the surface tension is decreased. Rise speed jump discontinuities were not found. (c) 2006 Elsevier B.V. All rights reserved